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http://hdl.handle.net/11690/3834
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Campo DC | Valor | Idioma |
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dc.contributor.author | Cioato, Stefania Giotti | - |
dc.contributor.author | Medeiros, Liciane Fernandes | - |
dc.contributor.author | Lopes, Bettega Costa | - |
dc.contributor.author | Medeiros, Helouise Richardt | - |
dc.contributor.author | Caumo, Wolnei | - |
dc.contributor.author | Roesler, Rafael | - |
dc.contributor.author | Torres, Iraci L.S. | - |
dc.date.accessioned | 2024-02-29T12:41:24Z | - |
dc.date.available | 2024-02-29T12:41:24Z | - |
dc.date.issued | 2022 | - |
dc.identifier.citation | CIOATO, S. G. et al. A3 receptor agonist modulates IL-1β hippocampus levels in a rat model of neuropathic pain. CLINICAL AND BIOMEDICAL RESEARCH, v. 42, p. 128-134, 2022. Disponível em: https://seer.ufrgs.br/index.php/hcpa/article/view/116706/85500. Acesso em:22 fev.2024 | pt_BR |
dc.identifier.uri | http://hdl.handle.net/11690/3834 | - |
dc.description.abstract | Introduction: Considering the lack of specific treatments for neuropathic pain, this study aimed to evaluate the effect of a single dose of adenosine A3 receptor IB-MECA on inflammatory and neurotrophic parameters in rats subjected to a neuropathic pain model. Methods: 64 adult male Wistar rats were used. Neuropathic pain was induced by chronic constriction injury (CCI) of the sciatic nerve and the treatment consisted of a 0.5 μmol/kg dose of IB-MECA, a selective A3 adenosine receptor agonist, dissolved in 3% DMSO; vehicle groups received DMSO 3% in saline solution, and morphine groups received 5 mg/kg. Cerebral cortex and hippocampus IL-1β, BDNF, and NGF levels were determined by Enzyme-Linked Immunosorbent assay. Results: The main outcome was that a single dose of IB-MECA was able to modulate the IL-1β hippocampal levels in neuropathic pain induced by CCI and the DMSO increased IL-1β and NGF hippocampal levels in sham-operated rats. However, we did not observe this effect when the DMSO was used as vehicle for IB-MECA, indicating that IB-MECA was able to prevent the effect of DMSO. Conclusions: Considering that the IL-1β role in neuropathic pain and the contributions of the hippocampus are well explored, our result corroborates the relationship between the A3 receptor and the process of chronic pain maintenance. | pt_BR |
dc.publisher | CLINICAL AND BIOMEDICAL RESEARCH | pt_BR |
dc.subject | Adenosine A3 receptor | pt_BR |
dc.subject | Cytokine | pt_BR |
dc.subject | DMSO | pt_BR |
dc.subject | IB-MECA | pt_BR |
dc.subject | Neuropathic pain | pt_BR |
dc.subject | Neurotrophin | pt_BR |
dc.subject | Rats | pt_BR |
dc.title | A3 receptor agonist modulates IL-1β hippocampus levels in a rat model of neuropathic pain | pt_BR |
dc.type | Other | pt_BR |
Aparece nas coleções: | Artigo de Periódico (PPGSDH) |
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ldufreitas,+CBR_42.2_RS_116706.pdf | Open Access | 1,19 MB | Adobe PDF | Visualizar/Abrir |
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