Use este identificador para citar ou linkar para este item:
http://hdl.handle.net/11690/1905
Autor(es): | Lopes, Bettega Costa Medeiros, Liciane Fernandes Stein, Dirson João Cioato, Stefania Giotti Souza, Vanessa Silva de Medeiros, Helouise Richardt Sanches, Paulo Roberto Stefani Fregni, Felipe Caumo, Wolnei Torres, Iraci L.S. |
Título: | tDCS and exercise improve anxiety-like behavior and locomotion in chronic pain rats via modulation of neurotrophins and inflammatory mediators |
Palavras-chave: | Anxiety;Biomarkers;Exercise;Pain;tDCS |
Data do documento: | 2021 |
Editor: | Elsevier |
Citação: | LOPES, B. C. et al. tDCS and exercise improve anxiety-like behavior and locomotion in chronic pain rats via modulation of neurotrophins and inflammatory mediators. Behavioural Brain Research, v. 404, p. 113173, abr. 2021. Disponível em: https://www.sciencedirect.com/science/article/abs/pii/S0166432821000607?via%3Dihub. Acesso em: 02 ago. 2021. |
Resumo: | Anxiety disorders cause distress and are commonly found to be comorbid with chronic pain. Both are difficult-to-treat conditions for which alternative treatment options are being pursued. This study aimed to evaluate the effects of transcranial direct current stimulation (tDCS), treadmill exercise, or both, on anxiety-like behavior and associated growth factors and inflammatory markers in the hippocampus and sciatic nerve of rats with neuropathic pain. Male Wistar rats (n = 216) were subjected to sham-surgery or sciatic nerve constriction for pain induction. Fourteen days following neuropathic pain establishment, either bimodal tDCS, treadmill exercise, or a combination of both was used for 20 min a day for 8 consecutive days. The elevated plus-maze test was used to assess anxiety-like behavior and locomotor activity during the early (24 h) or late (7 days) phase after the end of treatment. BDNF, TNF-ɑ, and IL-10 levels in the hippocampus, and BDNF, NGF, and IL-10 levels in the sciatic nerve were assessed 48 h or 7 days after the end of treatment. Rats from the pain groups developed an anxiety-like state. Both tDCS and treadmill exercise provided ethological and neurochemical alterations induced by pain in the early and/or late phase, and a modest synergic effect between tDCS and exercise was observed. These results indicate that non-invasive neuromodulatory approaches can attenuate both anxiety-like status and locomotor activity and alter the biochemical profile in the hippocampus and sciatic nerve of rats with neuropathic pain and that combined interventions may be considered as a treatment option. |
Aparece nas coleções: | Artigo de Periódico (PPGSDH) |
Arquivos associados a este item:
Arquivo | Descrição | Tamanho | Formato | |
---|---|---|---|---|
bclopes.etal.pdf Until 2070-01-01 | Closed Access | 3,95 MB | Adobe PDF | Visualizar/Abrir Solictar uma cópia |
Os itens no repositório estão protegidos por copyright, com todos os direitos reservados, salvo quando é indicado o contrário.