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Authors: Damiani, Lucas Petri
Cavalcanti, Alexandre Biasi
Biond, Rodrigo Santos
Freitas, Flávio Geraldo Rezende de
Figueiredo, Rodrigo Cruvinel
Lovato, Wilson José
Amêndola, Cristina Prata
Serpa Neto, Ary
Paranhos, Jorge Luiz da Rocha
Veiga, Viviane Cordeiro
Guedes, Marco Antonio Vieira
Lúcio, Eraldo de Azevedo
Oliveira Júnior, Lúcio Couto
Lisboa, Thiago
Lacerda, Fabio Holanda
Miranda, Tamiris Abait
Maia, Israel Silva
Grion, Cintia Magalhães Carvalho
Machado, Flavia Ribeiro
Zampieri, Fernando Godinho
Title: Statistical analysis plan for the Balanced Solution versus Saline in Intensive Care Study (BaSICS)
Keywords: Balanced solutions;Critical care;Normal saline;Saline solution;Acute kidney injury
Issue Date: 2020
Publisher: Associação de Medicina Intensiva Brasileira
Citation: DAMIANI, L. P. et al. Statistical analysis plan for the Balanced Solution versus Saline in Intensive Care Study (BaSICS). Rev. bras. ter. intensiva, v. 32, n. 4, p. 493-505, out./dez., 2020. Disponível em: Acesso em: 27 jul. 2021.
Abstract: Objective: To report the statistical analysis plan (first version) for the Balanced Solutions versus Saline in Intensive Care Study (BaSICS). Methods: BaSICS is a multicenter factorial randomized controlled trial that will assess the effects of Plasma-Lyte 148 versus 0.9% saline as the fluid of choice in critically ill patients, as well as the effects of a slow (333mL/h) versus rapid (999mL/h) infusion speed during fluid challenges, on important patient outcomes. The fluid type will be blinded for investigators, patients and the analyses. No blinding will be possible for the infusion speed for the investigators, but all analyses will be kept blinded during the analysis procedure. Results: BaSICS will have 90-day mortality as its primary endpoint, which will be tested using mixed-effects Cox proportional hazard models, considering sites as a random variable (frailty models) adjusted for age, organ dysfunction and admission type. Important secondary endpoints include renal replacement therapy up to 90 days, acute renal failure, organ dysfunction at days 3 and 7, and mechanical ventilation-free days within 28 days. Conclusion: This manuscript provides details on the first version of the statistical analysis plan for the BaSICS trial and will guide the study’s analysis when follow-up is finished.
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